Laboratory identity and procurement
A MOTS-c research peptide purchase starts with a defined material specification. The scientific literature identifies a mitochondrial-derived sequence; the supplied synthetic material still needs its own identity and lot documentation.
The commonly reported human MOTS-c sequence is MRWQEMGYIFYPRKLR, a 16-residue peptide. Sequence identity, analytical purity, measured content and fulfillment lot are separate purchasing checks.
What sequence does MOTS-c identify?
Lee and colleagues described MOTS-c in 2015 as a peptide associated with a short open reading frame in the mitochondrial 12S rRNA region. The commonly reported human sequence is MRWQEMGYIFYPRKLR. That sequence is written from the N-terminus to the C-terminus.
A laboratory order should not stop at the abbreviation. Record the sequence, terminal chemistry, declared form and any intended label or modification. A species variant, a labeled analogue or a modified terminus may be suitable for one project and unsuitable for another.
| Record field | What to check |
|---|---|
| Name | MOTS-c, with the complete stated identity |
| Residue count | 16 for the commonly reported human sequence |
| One-letter sequence | MRWQEMGYIFYPRKLR |
| Modifications | Explicitly state labels, terminal changes or substitutions |
| Supplier evidence | Identity assignment for the actual tested sample |
Endogenous peptide and synthetic research material
A paper about an endogenous peptide and a vial of synthetic research material are different evidence records. The paper provides the authors’ experimental context. The supplier record provides evidence about the material tested by the issuing laboratory. Neither record substitutes for the other.
Read the original study’s material description before comparing a catalog item with it. The abbreviation may be shared, but modifications, chemical form and analytical basis still need to match the project. Published findings do not certify a current supplier batch or establish a human-use outcome.
What a MOTS-c COA should help you review
Begin with the tested sample identity, lot identifier, issuer and report date. Then separate identity evidence from purity and quantity. HPLC area purity describes a chromatographic measurement. A nominal quantity on a label is not automatically a measurement of net peptide content.
For mass evidence, ask how the observed ion or mass assignment corresponds to the expected structure. Retention time alone is method-dependent and does not establish identity across different laboratories or gradients. Use the COA reading guide to record which conclusions the report actually supports.
- Identity: expected structure and the reported analytical assignment.
- Purity: stated method, detector and integration basis where available.
- Content: whether quantity is nominal or directly measured, and on what basis.
- Traceability: report-vial lot matching and current fulfillment confirmation.
- Project requirements: contaminants or other specifications required by the actual assay.
Receiving a lot for an in-vitro project
Agree on acceptance criteria before ordering. Some projects need more than the standard supplier report, including a particular content assay or contaminant limit. Request those specifications explicitly; do not infer sterility or endotoxin results from a purity percentage.
At receipt, retain the lot identifier, order reference and corresponding report version. Record packaging condition and any discrepancies before combining materials or placing repeat orders. If continuity matters, confirm whether a subsequent order can come from the same lot; do not assume it will.
Storage decisions should follow documented instructions and any available stability evidence for the supplied form. A paper describing another preparation does not establish a universal shelf life for your vial.
Reviewing SRL’s available MOTS-c documentation
Review the MOTS-c product listing alongside the published lot SRL-MS-101 report record. Confirm that the lot available for fulfillment matches the report relevant to your order.
Batch-specific analytical documentation is published for supported lots. Contact support if documentation for a specific lot is not listed. For a laboratory purchasing enquiry, send the required identity, quantity and acceptance specifications through SRL support. Do not assume unreported tests, guaranteed lot continuity or custom manufacture.
Frequently asked questions
Is MOTS-c the same as every mitochondrial-derived peptide?
No. MOTS-c is a specific sequence. Other mitochondrial-derived peptides have different identities and evidence records.
Does a research paper verify the material in a supplier vial?
No. The supplier’s lot-linked analytical record and your project’s acceptance requirements need separate review.
Can a purity percentage establish the amount of MOTS-c in the vial?
Not by itself. HPLC area purity and net peptide content are different measurements.
Do published MOTS-c findings establish longevity benefits for a customer?
No. This procurement reference does not establish human effects or authorize human use of research material.
Related procurement guides
Sources and scope
- Lee et al., Cell Metabolism (2015): original MOTS-c sequence and discovery context.
- MOTS-c laboratory study (2024): stated sequence and material identity context; no outcome recommendation is made here.
These sources support the stated chemical or research context. They do not authenticate an SRL lot or establish the suitability of a supplier material for a particular experiment. Source check: October 5, 2026.
